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Facile synthesis of octahydrobenzo[h]isoquinolines: Novel and highly potent D1 dopamine agonists

Lisa A. Bonner, Benjamin R. Chemel, Val J. Watts, David E. Nichols

Journal:

Bioorganic & Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 463 KB

english, 2010

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling

Brust, Tarsis F., Hayes, Michael P., Roman, David L., Watts, Val J.

Journal:

Biochemical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 355 KB

english, 2015

WAY-100635 is a potent dopamine D4receptor agonist

Benjamin R. Chemel, Bryan L. Roth, Blaine Armbruster, Val J. Watts, David E. Nichols

Journal:

Psychopharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 209 KB

english, 2006

Synthesis and Molecular Modeling of 1-Phenyl-1,2,3,4-tetrahydroisoquinolines and Related 5,6,8,9-Tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 Dopamine Antagonists

Minor, Deborah L., Wyrick, Steven D., Charifson, Paul S., Watts, Val J., Nichols, David E., Mailman, Richard B.

Journal:

Journal of Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 3.14 MB

english, 1994

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Dessauer, Carmen W., Watts, Val J., Ostrom, Rennolds S., Conti, Marco, Dove, Stefan, Seifert, Roland, Ohlstein, Eliot H.

Journal:

Pharmacological Reviews

Année:

2017

Langue:

english

Fichier:

PDF, 3.58 MB

english, 2017

A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and Cyclic AMP Signaling

Soto-Velasquez, Monica, Hayes, Michael P, Alpsoy, Aktan, Dykhuizen, Emily C, Watts, Val J

Journal:

Molecular Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 992 KB

english, 2018

Genomics, GPCRs and new targets for the control of insect pests and vectors

Hill, Catherine A, Sharan, Shruti, Watts, Val J

Journal:

Current Opinion in Insect Science

Année:

2018

Langue:

english

Fichier:

PDF, 391 KB

english, 2018

ChemInform Abstract: Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines.

Joseph B. Blair, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka, Medhane G. Cumbay, Val J. Watts, Eric L. Barker, David E. Nichols

Journal:

ChemInform

Année:

2001

Fichier:

PDF, 34 KB

2001

Mapping the Catechol Binding Site in Dopamine D1 Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues

Dr. Lisa A. Bonner, Dr. Uros Laban, Benjamin R. Chemel, Jose I. Juncosa, Prof. Markus A. Lill, Val J. Watts, Dr. David E. Nichols

Journal:

ChemMedChem

Année:

2011

Langue:

english

Fichier:

PDF, 596 KB

english, 2011

Viral-Mediated Gene Delivery Of Constitutively Activated GΑS Alters Vasoreactivity

William E Schutzer, Val J Watts, Justin Chapman, Medhane G Cumbay, Kim A Neve, Rachael L Neve, Scott L Mader

Journal:

Clinical and Experimental Pharmacology and Physiology

Année:

2000

Langue:

english

Fichier:

PDF, 113 KB

english, 2000

Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells

Christopher A. Johnston, Michael A. Beazely, Amanda F. Vancura, James K. T. Wang, Val J. Watts

Journal:

Journal of Neurochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 268 KB

english, 2002

A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases

Deborah M. Kurrasch-Orbaugh, Jason C. Parrish, Val J. Watts, David E. Nichols

Journal:

Journal of Neurochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 330 KB

english, 2003

Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line

Christopher A. Johnston, Michael A. Beazely, Matthew L. Bilodeau, Ourania Andrisani, Val J. Watts

Journal:

Journal of Neurochemistry

Année:

2004

Langue:

english

Fichier:

PDF, 848 KB

english, 2004

Sexual experience alters D1 receptor–mediated cyclic AMP production in the nucleus accumbens of female Syrian hamsters

Katherine C. Bradley, Amanda J. Mullins, Robert L. Meisel, Val J. Watts

Journal:

Synapse

Année:

2004

Langue:

english

Fichier:

PDF, 135 KB

english, 2004

Spare receptors and intrinsic activity: Studies with D1 dopamine receptor agonists

Val J. Watts, Cindy P. Lawler, Andrea J. Gonzales, Qun-Yong Zhou, Olmer Civelli, David E. Nichols, Richard B. Mailman

Journal:

Synapse

Année:

1995

Langue:

english

Fichier:

PDF, 1.27 MB

english, 1995

Interhemispheric modulation of dopamine receptor interactions in unilateral 6-OHDA rodent model

Cindy P. Lawler, John H. Gilmore, Val J. Watts, Q. David Walker, Stan B. Southerland, Larry L. Cook, Chet A. Mathis, Richard B. Mailman

Journal:

Synapse

Année:

1995

Langue:

english

Fichier:

PDF, 1.56 MB

english, 1995

Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters

Julia A. Chester, Amanda J. Mullins, Chau H. Nguyen, Val J. Watts, Robert L. Meisel

Journal:

Psychopharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 299 KB

english, 2006

Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors

Val J. Watts, Minh N. Vu, Brenda L. Wiens, Vera Jovanovic, Hubert H. M. Van Tol, Kim A. Neve

Journal:

Psychopharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 175 KB

english, 1999

Comparison of the D1dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease

McCorvy, John D., Watts, Val J., Nichols, David E.

Journal:

Psychopharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 235 KB

english, 2012

Concentration of enzyme-dependent activation of PLC-β1 and PLC-β2 by Gα11 and βγ-subunits

Andrew Paterson, JoséLuis Boyer, Val J. Watts, Andrew J. Morris, Elmer M. Price, T.Kendall Harden

Journal:

Cellular Signalling

Année:

1995

Langue:

english

Fichier:

PDF, 880 KB

english, 1995

Gαq-coupled receptor signaling enhances adenylate cyclase type 6 activation

Michael A. Beazely, Val J. Watts

Journal:

Biochemical Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 318 KB

english, 2005

Gαq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway

Medhane G. Cumbay, Val J. Watts

Journal:

Biochemical Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 461 KB

english, 2005

Assessment of dopamine D1 receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393

Alia H. Clark, John D. McCorvy, Val J. Watts, David E. Nichols

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 810 KB

english, 2011

Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6

Michael A. Beazely, Val J. Watts

Journal:

Cellular Signalling

Année:

2005

Langue:

english

Fichier:

PDF, 385 KB

english, 2005

Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines

Juan Pablo Cueva, Benjamin R. Chemel, Jose I. Juncosa Jr., Markus A. Lill, Val J. Watts, David E. Nichols

Journal:

European Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 531 KB

english, 2012

Regulatory properties of adenylate cyclases type 5 and 6: A progress report

Michael A. Beazely, Val J. Watts

Journal:

European Journal of Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 539 KB

english, 2006

Adenosine A2A receptors assemble into higher-order oligomers at the plasma membrane

Pierre-Alexandre Vidi, Jiji Chen, Joseph M.K. Irudayaraj, Val J. Watts

Journal:

FEBS Letters

Année:

2008

Langue:

english

Fichier:

PDF, 349 KB

english, 2008

Sensitization of adenylate cyclase by Gαi/o-coupled receptors

Val J. Watts, Kim A. Neve

Journal:

Pharmacology & Therapeutics

Année:

2005

Langue:

english

Fichier:

PDF, 889 KB

english, 2005

Structure of Gαi1 Bound to a GDP-Selective Peptide Provides Insight into Guanine Nucleotide Exchange

Christopher A. Johnston, Francis S. Willard, Mark R. Jezyk, Zoey Fredericks, Erik T. Bodor, Miller B. Jones, Rainer Blaesius, Val J. Watts, T. Kendall Harden, John Sondek, J. Kevin Ramer, David P. Sid

Journal:

Structure

Année:

2005

Langue:

english

Fichier:

PDF, 868 KB

english, 2005

Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors

Joshua G. Lisinicchia, Val J. Watts

Journal:

Cellular Signalling

Année:

2003

Langue:

english

Fichier:

PDF, 198 KB

english, 2003

Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents

Val J. Watts, Cindy P. Lawler, John H. Gilmore, Stan B. Southerland, David E. Nichols, Richard B. Mailman

Journal:

European Journal of Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 875 KB

english, 1993

Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands

Val J. Watts, Cindy P. Lawler, Timm Knoerzer, Mechelle A. Mayleben, Kim A. Neve, David E. Nichols, Richard B. Mailman

Journal:

European Journal of Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 201 KB

english, 1993

Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1

Chau H. Nguyen, Val J. Watts

Journal:

Biochemical and Biophysical Research Communications

Année:

2005

Langue:

english

Fichier:

PDF, 400 KB

english, 2005

A bifunctional Gαi/Gαs modulatory peptide that attenuates adenylyl cyclase activity

Christopher A. Johnston, J. Kevin Ramer, Rainer Blaesius, Zoey Fredericks, Val J. Watts, David P. Siderovski

Journal:

FEBS Letters

Année:

2005

Langue:

english

Fichier:

PDF, 396 KB

english, 2005

Molecular and pharmacological characterization of two D1-like dopamine receptors in the Lyme disease vector, Ixodes scapularis

Jason M. Meyer, Karin F.K. Ejendal, Val J. Watts, Catherine A. Hill

Journal:

Insect Biochemistry and Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 832 KB

english, 2011

Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling

Pierre-Alexandre Vidi, Karin F.K. Ejendal, Julie A. Przybyla, Val J. Watts

Journal:

Molecular and Cellular Endocrinology

Année:

2011

Langue:

english

Fichier:

PDF, 777 KB

english, 2011

D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is Gαs independent

Timothy A. Vortherms, Chau H. Nguyen, Murat Bastepe, Harald Jüppner, Val J. Watts

Journal:

Neuropharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 308 KB

english, 2006

Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D2L cells

Christopher A Johnston, Medhane G Cumbay, Timothy A Vortherms, Val J Watts

Journal:

FEBS Letters

Année:

2001

Langue:

english

Fichier:

PDF, 181 KB

english, 2001

Sensitization of adenylate cyclase: A general mechanism of neuroadaptation to persistent activation of Gαi/o-coupled receptors?

Christopher A Johnston, Val J Watts

Journal:

Life Sciences

Année:

2003

Langue:

english

Fichier:

PDF, 398 KB

english, 2003

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand

Alia H. Clark, John D. McCorvy, Jason M. Conley, Whitney K. Williams, Markondaiah Bekkam, Val J. Watts, David E. Nichols

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 572 KB

english, 2012

Conformational Analysis of D 1 Dopamine Receptor Agonists: Pharmacophore Assessment and Receptor Mapping †

Mottola, David M., Laiter, Sergei, Watts, Val J., Tropsha, Alexander, Wyrick, Steven D., Nichols, David E., Mailman, Richard B.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 512 KB

english, 1996

trans -2,3-Dihydroxy-6a,7,8,12b-tetrahydro-6 H -chromeno[3,4- c ]isoquinoline: Synthesis, Resolution, and Preliminary Pharmacological Characterization of a New Dopamine D 1 Receptor Full Agonist

Cueva, Juan Pablo, Giorgioni, Gianfabio, Grubbs, Russell A., Chemel, Benjamin R., Watts, Val J., Nichols, David E.

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 280 KB

english, 2006

Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors

Julie A. Przybyla, Juan P. Cueva, Benjamin R. Chemel, K. Joseph Hsu, David J. Riese II, John D. McCorvy, Julia A. Chester, David E. Nichols, Val J. Watts

Journal:

European Neuropsychopharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 649 KB

english, 2009

Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses

Ejendal, Karin F.K., Meyer, Jason M., Brust, Tarsis F., Avramova, Larisa V., Hill, Catherine A., Watts, Val J.

Journal:

Insect Biochemistry and Molecular Biology

Année:

2012

Langue:

english

Fichier:

PDF, 648 KB

english, 2012

Further Definition of the D 1 Dopamine Receptor Pharmacophore: Synthesis of trans -6,6a,7,8,9,13b-Hexahydro-5 H -benzo[ d ]naphth[2,1- b ]azepines as Rigid Analogues of β-Phenyldopamine

Negash, Kitaw, Nichols, David E., Watts, Val J., Mailman, Richard B.

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 343 KB

english, 1997

Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines

Blair, Joseph B., Kurrasch-Orbaugh, Deborah, Marona-Lewicka, Danuta, Cumbay, Medhane G., Watts, Val J., Barker, Eric L., Nichols, David E.

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 114 KB

english, 2000

Re-invigorating the insecticide discovery pipeline for vector control: GPCRs as targets for the identification of next gen insecticides

Hill, Catherine A., Meyer, Jason M., Ejendal, Karin F.K., Echeverry, Diego F., Lang, Emma G., Avramova, Larisa V., Conley, Jason M., Watts, Val J.

Journal:

Pesticide Biochemistry and Physiology

Année:

2013

Langue:

english

Fichier:

PDF, 983 KB

english, 2013

Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience

Staffend, Nancy A., Hedges, Valerie L., Chemel, Benjamin R., Watts, Val J., Meisel, Robert L.

Journal:

Brain Structure and Function (Anatomy and Embryology 1891-2006)

Année:

2014

Langue:

english

Fichier:

PDF, 593 KB

english, 2014

Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers

Park, Joonyoung, Brust, Tarsis F., Lee, Hong Jae, Lee, Sang Cheon, Watts, Val J., Yeo, Yoon

Journal:

ACS Nano

Année:

2014

Langue:

english

Fichier:

PDF, 6.25 MB

english, 2014

8,9-Dihydroxy-2,3,7,11b-tetrahydro-1 H -naph[1,2,3- de ]isoquinoline: A Potent Full Dopamine D 1 Agonist Containing a Rigid β-Phenyldopamine Pharmacophore

Ghosh, Debasis, Snyder, Scott E., Watts, Val J., Mailman, Richard B., Nichols, David E.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 272 KB

english, 1996